Deep whole-genome analysis of 494 hepatocellular carcinomas.
Author: Lei Chen, Chong Zhang, Ruidong Xue
Interpretation >
Polyamine metabolism controls B-to-Z DNA
transition to orchestrate DNA sensor cGAS activity
Author: Chunyuan Zhao, Yunjin Ma, Minghui Zhang
Interpretation >
Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: A new function and mechanism
Author: Yueyue Liu, ∙ Tianchi Duan, ∙ Chao Guo ∙ Bin Liu ∙ Xiuqiong Fu ∙ Lu Wang ∙ Xiaoyuan Wang ∙ Xinyue Dong ∙ Chennan Wang ∙ Yalong Lu ∙ Yu Wang ∙ Lin Shi ∙ Honglei Tian ∙ Xingbin Yang
Nuclear miR-204-3p mitigates metabolic dysfunction-associated steatotic liver disease in mice
Author: Zhaowei Zou, Xiu Liu, Jie Yu
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
Author: Juhong Wang, Yannan Yang, Fei Shao
Interpretation >
Targeted chemotherapy via HER2-based chimeric antigen receptor (CAR) engineered T-cell membrane coated polymeric nanoparticles.
Author: Serkan Yaman, Harish Ramachandramoorthy, Priyanka Iyer
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders.
Author: Melissa Lim, Thang Do Cong, Lauren M. Orr
Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA
Author: Ya′nan Zhu, Jing He, Jiawen Wang
Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Author: Hudie Wei, Haolan Wang, Genxin Wang
Interpretation >
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation
Author: Junnan Liang, Ganxun Li, Jingyu Liao
Interpretation >
Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes
Author: Ye Zhu 1 2, Yukang Zhang 1 2, Zhuying Fan 1 2
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
Author: Julia O’Sullivan, Charu Kothari, Marie-Christine Caron
C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial
Author: Shiyu Zuo, Chuo Li, Xiaolei Sun
piRNA PROPER Suppresses DUSP1 Translation by Targeting N6-Methyladenosine-Mediated RNA Circularization to Promote Oncogenesis of Prostate Cancer
Author: Shuai Ben, Zhutao Ding, Junyi Xin
The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia
Author: Xiaoyuan Bai ，Wenxian Yang ，Yuna Zhao，Tongtong Cao，Runshan Lin，Pengtao Jiao，Heqiao Li，Huizi Li，Jie Min，Xiaoxiao Jia，He Zhang，Wenhui Fan，Xiaojuan Jia，Yuhai Bi，Wenjun Liu，Lei Sun
Interpretation >
Peptide-based allosteric inhibitor targets TNFR1 conformationally
active region and disables receptor–ligand signaling complex
Author: Jialiu Zeng,Gavin Wen Zhao Loi,Eka Norfaishanty Saipuljumria,Marco Antonio Romero Duránc, Octavio Silva-Garcíac, Jose Manuel Perez-Aguilard
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux
Author: Xiaoxiao Ji a b c d 1, Jianqiao Hong b c d 1, Weinan Yang b c d 1
Interpretation >
TNFR2 deficiency impairs the growth of mouse colon cancer
Author: Ping Li1, Yang Yang1, Xinyu Yang1
O-GlcNAcylation of ATP-citrate lyase couples glucose supply to lipogenesis for rapid tumor cell proliferation
Author: Jia Liu , Yang Wang, Miaomiao Tian
Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
Author: Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan
Interpretation >
FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
Author: Xinran Qiao, Jingyu Lin, Jiajia Shen
MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development
Author: Alison Robert ,David Crottès ,Jérôme Bourgeais,Naig Gueguen,Arnaud Chevrollier,Jean-François Dumas,Stéphane Servais,Isabelle Domingo,Stéphanie Chadet,Julien Sobilo,Olivier Hérault,Thierry Lecomte,Christophe Vandier,William Raoul,Maxime Guéguinou
Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis
Author: Mengqi Sun, Qinglin Sun, Tianyu Li
USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
Author: Bin Huang, ∙ Dan Cao, ∙ Xiao Yuan ∙ Yuxian Xiong ∙ Bingzhang Chen
Mass Spectrometry Analysis of Glycopeptides Enriched by Anion Exchange-Mediated Methods Reveals PolyLacNAc-Extended N-Glycans in Integrins and Tetraspanins in Melanoma Cells
Author: Tomislav Čaval, Gege Xu, Maryam Baniasad
CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72
Author: Zhenguang Ying, Kaifang Wang, Junfeng Wu
Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
Author: Jia-Hui Su, Yu Hong, Cong-Cong Han
C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma
Author: Xuejun Wu, Zhengzhong Ni, Tiantian Song
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
Author: Jian Zhang, Lingyan Zhang, Gang Yao
Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C
Author: Sepideh Mikaeeli ,Ali Ben Djoudi Ouadda ,Alexandra Evagelidis ,Rachid Essalmani
,Oscar Henrique Pereira Ramos ,Carole Fruchart-Gaillard and Nabil G. Seidah
LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Disease Cell Model
Author: Wei Zheng, Xiao Han, Bing Han
Abnormal expression of CUX1 influences autophagy activation in paroxysmal 2 nocturnal hemoglobinuria
Author: Junshu Wu, Liyan Li, Zhaoyun Liu
TLR2 regulates Moraxella catarrhalis adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses.
Author: Rui DingORCID Icon, Jinhan Yu, Weixin Ke
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation
Author: Wenxue Gu, Hongyan Zheng, Cecilia M. Canessa
HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice
Author: Miaomiao Bie, Yi Tang, Yuxing Xia
Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Author: Worapong Khaodee, Guo Xiyuan, Moe Thi Thi Han
SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor
Author: Cuiling Zhang, Qiwei Jiang, Zirui Liu
Nuclear receptor corepressor 1 levels differentially impact the intracellular dynamics of mutant thyroid hormone receptors associated with resistance to thyroid hormone syndrome
Author: Yigit K. Simsek, H. Page Tofil, Matthew I. Rosenthal
Construction of TSC2 knockout cell line using CRISPR/Cas9 system and demonstration of its effects on NIH-3T3 cells
Author: Xu Wang, Yang Zhao, Zhan Wang
Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by Schistosoma Japonicum Infection.
Author: Zhihao Yu, Tingting Jiang, Fangfang Xu
NRF2 Protects Lung Epithelial Cells from Wood Smoke Particle Toxicity
Author: Sarah E. Lacher ，Tessa Schumann ，Ryan Peters ,Christopher Migliaccio c, Andrij Holian c， Matthew Slattery
Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
Author: Eros Di Giorgio，Vanessa Tolotto，Nicolò Gualandi，Monica Colitti，Raffaella Picco，Ylenia Cortolezzis，Francesca D'Este，Mariachiara Gani，Wayne Hancock，Giovanni Terrosu，Cristina Degrassi，Claudio Brancolini，Luigi Xod
Many erroneous noncoding transcripts in cancer cells can highly specifically regulate cancer-related genes and pathways
Author: Sha He, Wei Xiong, Jianping Huo
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders
Author: Melissa Lim, Thang Do Cong, Lauren M. Orr
The Degradation Mechanisms of Aryl Hydrocarbon Receptor in Human Lung Epithelial
Carcinoma A549 Cells
Encoding of the colorectal cancer metabolic program
through MICU2
Author: Alison Robert, David Crottès, Jérôme Bourgeais
A new polymodal gating model of the proton-activated chloride channel
Author: Zhao P, Tang C, Yang Y
Commercially Available Reagents and Contract Research Services for CRISPR‐Based Studies
Author: Klio Maratou, Aaron T. Cheng, Fiona M. Behan
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating 2 gene expression
Author: Jie Lin, Yujian Wen, Ji Tang
A novel mutation causing complete TYK2 deficiency, with severe respiratory viral infections, EBV-driven lymphoma, and Jamestown Canyon viral encephalitis
Author: Lucie Roussel, Anne Pham-Huy, Andrea C Yu
