Deep whole-genome analysis of 494 hepatocellular carcinomas.
Author: Lei Chen, Chong Zhang, Ruidong Xue
Interpretation >
Polyamine metabolism controls B-to-Z DNA
transition to orchestrate DNA sensor cGAS activity
Author: Chunyuan Zhao, Yunjin Ma, Minghui Zhang
Interpretation >
Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: A new function and mechanism
Author: Yueyue Liu, ∙ Tianchi Duan, ∙ Chao Guo ∙ Bin Liu ∙ Xiuqiong Fu ∙ Lu Wang ∙ Xiaoyuan Wang ∙ Xinyue Dong ∙ Chennan Wang ∙ Yalong Lu ∙ Yu Wang ∙ Lin Shi ∙ Honglei Tian ∙ Xingbin Yang
Nuclear miR-204-3p mitigates metabolic dysfunction-associated steatotic liver disease in mice
Author: Zhaowei Zou, Xiu Liu, Jie Yu
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
Author: Juhong Wang, Yannan Yang, Fei Shao
Interpretation >
Targeted chemotherapy via HER2-based chimeric antigen receptor (CAR) engineered T-cell membrane coated polymeric nanoparticles.
Author: Serkan Yaman, Harish Ramachandramoorthy, Priyanka Iyer
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders.
Author: Melissa Lim, Thang Do Cong, Lauren M. Orr
DEPDC1 is a potential therapeutic target in lung adenocarcinoma
Author: Liuxiang Wang , Yueguang Xue , Xinlian Wang
Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA
Author: Ya′nan Zhu, Jing He, Jiawen Wang
Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Author: Hudie Wei, Haolan Wang, Genxin Wang
Interpretation >
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation
Author: Junnan Liang, Ganxun Li, Jingyu Liao
Interpretation >
Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes
Author: Ye Zhu 1 2, Yukang Zhang 1 2, Zhuying Fan 1 2
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer
Author: Rong Wang, Yuanyuan Mi, Jiang Ni
Interpretation >
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
Author: Julia O’Sullivan, Charu Kothari, Marie-Christine Caron
C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial
Author: Shiyu Zuo, Chuo Li, Xiaolei Sun
piRNA PROPER Suppresses DUSP1 Translation by Targeting N6-Methyladenosine-Mediated RNA Circularization to Promote Oncogenesis of Prostate Cancer
Author: Shuai Ben, Zhutao Ding, Junyi Xin
The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia
Author: Xiaoyuan Bai ，Wenxian Yang ，Yuna Zhao，Tongtong Cao，Runshan Lin，Pengtao Jiao，Heqiao Li，Huizi Li，Jie Min，Xiaoxiao Jia，He Zhang，Wenhui Fan，Xiaojuan Jia，Yuhai Bi，Wenjun Liu，Lei Sun
Interpretation >
Salmonella manipulates macrophage migration via SteC-mediated myosin light chain activation to penetrate the gut-vascular barrier.
Author: Yuanji Dai, Min Zhang, Xiaoyu Liu
Interpretation >
Peptide-based allosteric inhibitor targets TNFR1 conformationally
active region and disables receptor–ligand signaling complex
Author: Jialiu Zeng,Gavin Wen Zhao Loi,Eka Norfaishanty Saipuljumria,Marco Antonio Romero Duránc, Octavio Silva-Garcíac, Jose Manuel Perez-Aguilard
OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy
Author: Yongkang Yu, Tingxuan Li, Meitong Ou
Interpretation >
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux
Author: Xiaoxiao Ji a b c d 1, Jianqiao Hong b c d 1, Weinan Yang b c d 1
Interpretation >
TNFR2 deficiency impairs the growth of mouse colon cancer
Author: Ping Li1, Yang Yang1, Xinyu Yang1
Loss‐of‐function variants in RNA binding motif protein X‐linked induce neuronal defects contributing to amyotrophic lateral sclerosis pathogenesis
Author: Di He, Xinyi He, Dongchao Shen
Deterministic Single-Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti-Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells
Author: Hangjun Si, Yuanzhuo Chen, Kun Jiang
O-GlcNAcylation of ATP-citrate lyase couples glucose supply to lipogenesis for rapid tumor cell proliferation
Author: Jia Liu , Yang Wang, Miaomiao Tian
Engineered P2Y12-Overexpressing Cell-Membrane-Wrapped Nanoparticles for the Functional Reversal of Ticagrelor and Clopidogrel
Author: Xiao Guo，Siping Ye，Xiaoyu Cheng，Yubiao Huang，Ge SunYang ，AnJiarui Du，Zhenzhen Dong，Guangjun Nie，Yinlong Zhang*
Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
Author: Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan
Interpretation >
GPR50 regulates neuronal development as a mitophagy receptor
Author: Ji-Chuan Liu, Xiu-Yun Zhao, Ming-Lei Wu
Construction of tandem diabody (IL-6/CD20)-secreting human umbilical cord mesenchymal stem cells and its experimental treatment on diffuse large B cell lymphoma
Author: Jiayi Zhang, Minglu Zhong, Weijie Zhong
FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
Author: Xinran Qiao, Jingyu Lin, Jiajia Shen
MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development
Author: Alison Robert ,David Crottès ,Jérôme Bourgeais,Naig Gueguen,Arnaud Chevrollier,Jean-François Dumas,Stéphane Servais,Isabelle Domingo,Stéphanie Chadet,Julien Sobilo,Olivier Hérault,Thierry Lecomte,Christophe Vandier,William Raoul,Maxime Guéguinou
Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis
Author: Mengqi Sun, Qinglin Sun, Tianyu Li
USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
Author: Bin Huang, ∙ Dan Cao, ∙ Xiao Yuan ∙ Yuxian Xiong ∙ Bingzhang Chen
Mass Spectrometry Analysis of Glycopeptides Enriched by Anion Exchange-Mediated Methods Reveals PolyLacNAc-Extended N-Glycans in Integrins and Tetraspanins in Melanoma Cells
Author: Tomislav Čaval, Gege Xu, Maryam Baniasad
CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72
Author: Zhenguang Ying, Kaifang Wang, Junfeng Wu
Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
Author: Jia-Hui Su, Yu Hong, Cong-Cong Han
Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction
Author: Yue Zheng, Yuchao Wang, Bingcai Qi
Porphyromonas gingivalis suppresses oral squamous cell carcinoma progression by inhibiting MUC1 expression and remodeling the tumor microenvironment
Author: Zhou Lan, Ke-Long Zou, Hao Cui
Gas Flow Shaping via Novel Modular Nozzle System (MoNoS) Augments kINPen-Mediated Toxicity and Immunogenicity in Tumor Organoids
Author: Julia Berner, Lea Miebach, Luise Herold
C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma
Author: Xuejun Wu, Zhengzhong Ni, Tiantian Song
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
Author: Jian Zhang, Lingyan Zhang, Gang Yao
SARS-CoV-2 receptor binding domain radio-probe a
non-invasive approach for angiotensin-converting enzyme
2 mapping in mice
Author: Dan Li, Jin Ding, Te-li Liu
Interpretation >
Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C
Author: Sepideh Mikaeeli ,Ali Ben Djoudi Ouadda ,Alexandra Evagelidis ,Rachid Essalmani
,Oscar Henrique Pereira Ramos ,Carole Fruchart-Gaillard and Nabil G. Seidah
Transcobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism.
Author: Baoyi Liu,Ang Li,Yi Liu,Xinzhu Zhou,Jingkai Xu，Xianbo Zuo，Ke Xue，Yong Cui*
LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Disease Cell Model
Author: Wei Zheng, Xiao Han, Bing Han
Abnormal expression of CUX1 influences autophagy activation in paroxysmal 2 nocturnal hemoglobinuria
Author: Junshu Wu, Liyan Li, Zhaoyun Liu
TLR2 regulates Moraxella catarrhalis adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses.
Author: Rui DingORCID Icon, Jinhan Yu, Weixin Ke
Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies
Author: Jiraporn Ousingsawat,Rainer Schreiber and Karl Kunzelmann
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation
Author: Wenxue Gu, Hongyan Zheng, Cecilia M. Canessa
Case report Novel TBX5-related pathogenic mechanism of Holt–Oram syndrome
Author: Yuheng Lang, Yue Zheng, Bingcai Qi
18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of neuroendocrine tumors (NETs)
Author: Fei Gao, Yunhan Zhang, MengYi Chen
HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice
Author: Miaomiao Bie, Yi Tang, Yuxing Xia
MiR-494-3p regulates skin fibroblast activities by mediating fibromodulin production
Author: Feng Zhao, Linshu Wang, Yuxin Zhang
Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Author: Worapong Khaodee, Guo Xiyuan, Moe Thi Thi Han
SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor
Author: Cuiling Zhang, Qiwei Jiang, Zirui Liu
Nuclear receptor corepressor 1 levels differentially impact the intracellular dynamics of mutant thyroid hormone receptors associated with resistance to thyroid hormone syndrome
Author: Yigit K. Simsek, H. Page Tofil, Matthew I. Rosenthal
Abnormal expression of CUX1 influences autophagy activation in paroxysmal nocturnal hemoglobinuria
Author: Junshu Wu, Liyan Li, Zhaoyun Liu
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
Author: Eirik Tveit Solheim, Yola Gerking, Torbjørn Kråkenes
Construction of TSC2 knockout cell line using CRISPR/Cas9 system and demonstration of its effects on NIH-3T3 cells
Author: Xu Wang, Yang Zhao, Zhan Wang
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair
Author: Jie Du , Fuqiang Chen, Zihan Chen
Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by Schistosoma Japonicum Infection.
Author: Zhihao Yu, Tingting Jiang, Fangfang Xu
HTR3A Promotes Non-small Cell Lung Cancer Through the FOXH1/Wnt3A Signaling Pathway
Author: Zeqin Wu, Jiufei Li, Minglian Zhong
NRF2 Protects Lung Epithelial Cells from Wood Smoke Particle Toxicity
Author: Sarah E. Lacher ，Tessa Schumann ，Ryan Peters ,Christopher Migliaccio c, Andrij Holian c， Matthew Slattery
Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
Author: Eros Di Giorgio，Vanessa Tolotto，Nicolò Gualandi，Monica Colitti，Raffaella Picco，Ylenia Cortolezzis，Francesca D'Este，Mariachiara Gani，Wayne Hancock，Giovanni Terrosu，Cristina Degrassi，Claudio Brancolini，Luigi Xod
Many erroneous noncoding transcripts in cancer cells can highly specifically regulate cancer-related genes and pathways
Author: Sha He, Wei Xiong, Jianping Huo
Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing
Author: Nikole L. Fendler, Jimmy Ly, Luisa Welp
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders
Author: Melissa Lim, Thang Do Cong, Lauren M. Orr
The Degradation Mechanisms of Aryl Hydrocarbon Receptor in Human Lung Epithelial
Carcinoma A549 Cells
Encoding of the colorectal cancer metabolic program
through MICU2
Author: Alison Robert, David Crottès, Jérôme Bourgeais
Machine learning-based pathomics model to predict the infiltration of regulatory T cells and prognosis in isocitrate dehydrogenase-wild- type glioblastoma
Author: Shaoli Peng, Xuezhen Wang, Jinyang Chen
A new polymodal gating model of the proton-activated chloride channel
Author: Zhao P, Tang C, Yang Y
Commercially Available Reagents and Contract Research Services for CRISPR‐Based Studies
Author: Klio Maratou, Aaron T. Cheng, Fiona M. Behan
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating 2 gene expression
Author: Jie Lin, Yujian Wen, Ji Tang
A novel mutation causing complete TYK2 deficiency, with severe respiratory viral infections, EBV-driven lymphoma, and Jamestown Canyon viral encephalitis
Author: Lucie Roussel, Anne Pham-Huy, Andrea C Yu
Optical control of CRISPR-Cas editing with cyclically caged guide RNAs
Author: Ying-Jie Sun, Ji Liu, Jun-Jin Li
Interpretation >
