Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
Author: Juhong Wang, Yannan Yang, Fei Shao
Interpretation >
Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
Author: Zihang Pan, ∙ Qiyang Yao, ∙ Weijing Kong ∙ Xiaojing Ma ∙ Liangliang Tian ∙ Yun Zhao ∙ Shuntian Zhu ∙ Sheng Chen ∙ Mengze Sun ∙ Jiao Liu ∙ Simin Jiang ∙ Jianxun Ma ∙ Qijia Liu ∙ Xiaohong Peng ∙ Xiaoxia Li ∙ Zixuan Hong ∙ Yi Hong ∙ Xue Wang ∙ Jiarui Liu ∙ Jingjing Zhang ∙ Wei Zhang ∙ Bingbing Sun ∙ Sara Pahlavan ∙ Youchen Xia ∙ Weimin Shen ∙ Yuyong Liu ∙ Wenjian Jiang ∙ Zhengwei Xie ∙ Wei Kong∙ Xi Wang,
Adaptive Design of Nanovesicles Overcoming Immunotherapeutic Limitations of Chemotherapeutic Drugs through Poliovirus Receptor Blockade.
Author: Yongkang Yu, Fan Zhang, Wenqing Xiao
Interpretation >
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition
Author: Minglu Zhou, Chendong Liu, Bo Li
Interpretation >
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.
Author: Lu-ning Qin, Heng Zhang, Qing-qing Li
Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases
Author: Chandra C Ghosh, Lauren Cournoyer, Yujia Liu
Biomimetic MDSCs membrane coated black phosphorus nanosheets system for photothermal therapy/photodynamic therapy synergized chemotherapy of cancer
Author: Zhou Lan, Wei-Jia Liu, Wu-Wei Yin
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy
Author: Dize Zhang, Bohan Ma, Donghua Liu
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A Macrophage Membrane–Polymer Hybrid Biomimetic Nanoplatform for Therapeutic Delivery of Somatostatin Peptide to Chronic Pancreatitis
Author: Fang Wang 1, 2, †ORCID
The effect of the nucleolar protein ZNF385A on the ribosomal DNA copy number variation in response to Cr(VI)-induced DNA damage
Author: Huadong Xu , Fan Wu , Chan Ding
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Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption
Author: Huichen Song ，Huanhuan Shi ，Mengru Ji ，Jiaqi Ding，Lin Cong，Silin Chen，Jiahui Zhou，Xinyan Zha，Jinyang Ye，Runcheng Li，Xiaoyu Hou，Siyu Mao，Xiaohong Jiang，Wen Zhang，Jing Li，Yujing Zhang
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Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/ A9
Author: Ting Wang, Chaoran Zhao, Jiahuan Zhang
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FOSL2 Is Involved in the Regulation of Glycogen Content in Chicken Breast Muscle Tissue
Author: Xiaojing Liu, Lu Liu, Jie Wang
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Single-cell and bulk transcriptomic datasets enable the development of prognostic models based on dynamic changes in the tumor immune microenvironment in patients with hepatocellular carcinoma and portal vein tumor thrombus
Author: Wangxia Tong&#x;Wangxia Tong†Jieyue Zhong&#x;Jieyue Zhong†Qiuyan Yang&#x;Qiuyan Yang†Han LinHan LinBolun ChenBolun ChenTao Lu*&#x;Tao Lu*‡Jibing Chen*&#x;Jibing Chen*‡Ning Luo*&#x;Ning Luo*‡
Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model
Author: Wen-Kai Chen； Lin-Juan Feng； Qiao-Dan Liu；Qing-Feng Ke, Pei-Ya Cai, Pei-Ru Zhang
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Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS–STING pathway in hepatocellular carcinoma
Author: Yan Xu, Fang Sun, Yuying Tian
Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway
Author: Xiaodong Cui, Xiaoxia Li, Yanting He
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Inhibition of autophagy suppresses SARS-CoV-2 replication and ameliorates pneumonia in hACE2 transgenic mice and xenografted human lung tissues
Author: Chao Shang，Xinyu Zhuang，He Zhang， Yiquan Li， Yilong Zhu， Jing Lu，Chenchen Ge，Jianan Cong，Tingyu Li，Nan Li，Mingyao Tian，Ningyi Jin, and Xiao Li
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Toxoplasma gondii microneme protein MIC3 induces macrophage TNF-α production and Ly6C expression via TLR11/MyD88 pathway
Author: Jingfan Qiu, Yanci Xie, Chenlu Shao
Disrupting CENP-N mediated SEPT9 methylation as a strategy to inhibit aerobic glycolysis and liver metastasis in colorectal cancer
Author: Junge Bai, Zhexue Wang, Ming Yang
TGM2 inhibits the proliferation, migration and tumorigenesis of MDCK cells
Author: Zhenyu Qiu, Shouqing Guo, Geng Liu
A non‐canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT).
Author: Li Chen, Yikai Lu, Mengmeng Zhao
Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer.
Author: Meng Chena,Shengli Ma， Wenbo Ji， Weihua Hud ∙ Jiguang Gaoa，Jianke Yanga， Yu Liub, Qianwen Cuib,Shasha Yang， Xiaohui Xua， Haiming Daib,∙ Lei Hu
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
Author: Eirik Tveit Solheim, Yola Gerking, Torbjørn Kråkenes
PKR downregulation prevents copper-induced synaptic dysfunction and cognitive impairment in a murine model of Wilson’s disease
Author: Chenchen Xu,Songyang LiuSongyang LiuNan Cheng,*Nan Cheng,*Yongsheng Han,*Yongsheng Han,*Xinheng Wang*Xinheng Wang*
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PET imaging of an optimized anti-PD-L1
probe 68Ga-NODAGA-BMS986192
in immunocompetent mice and non-human
primates
Author: Huimin Zhou1, Guangfa Bao1, Ziqiang Wang1
Long noncoding RNAs AC026904.1 is essential for TGF-β-induced migration and epithelial-mesenchymal
transition through functioning as an enhancer of Slug in lung cancer cells
Author: Jie Yao, Xiaochen Lu, Yuxuan Wang
Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B-cell lymphoma
Author: Chin-Mu Hsu Shih-Yu Kao Chia-Hung Yen Chi-En Hsiao Shih-Feng Cho Hui-Ching Wang Tsung-Jang Yeh Jeng-Shiun Du Min-Hong Wang Tzu-Yu Hsieh Samuel Yien Hsiao Yuhsin Tsai Li-Chuan Hung Yi-Chang Liu Kung-Chao Chang Hui-Hua Hsiao
Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency
Author: Kexin Peng, Wenghong Wong, Qiaoan Zhang
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Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
Author: Eros Di Giorgio，Vanessa Tolotto，Nicolò Gualandi，Monica Colitti，Raffaella Picco，Ylenia Cortolezzis，Francesca D'Este，Mariachiara Gani，Wayne Hancock，Giovanni Terrosu，Cristina Degrassi，Claudio Brancolini，Luigi Xod
Analysis and identification of mitochondrial DNA associated with age-related hearing loss
Author: Tianyu ma，Xiaoyun Zeng，Mengting Liu，Shijia Xu，Yuyao Wang，Qilong Wu，Tianhong Zhang
A receptor-independent signaling pathway for BDNF
Author: Julia Fath, Franck Brouillard, Alexandre Cabaye
